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What is Mitragynine? A Complete Guide.

If you’re familiar with kratom, you’ve probably heard mention of mitragynine. It’s often referred to in the kratom community as ‘mit’. This is a vital part of the kratom plant. It’s a major part of why kratom is effective for a number of different things. In many cases, the more mit in a kratom strain, the more effective it will be for consumers. That’s why mit content is important to think about when you’re shopping for kratom. This is especially true if you’re shopping for kratom online and can’t see the quality in person! That’s why having third-party lab testing (like we do on all our GRH kratom products) is vital- it can show you the mit content inside.
We are not chemistry experts nor medical professionals. This is merely our best understanding of the subject and should not be taken as medical advice.

Keep in mind- mit content should be within an average range. Kratom that boasts extremely high mit content may not be pure kratom. It could have been adulterated in order to gain higher alkaloid content.

In this blog, we’re going to dive into the nitty gritty of mitragynine. What it is, what it does, and what makes it so interesting. Let’s go ahead and start.
Mitragynine is an alkaloid found in the leaves of the Kratom tree (Mitragyna speciosa), which is a tropical evergreen plant that’s native to several countries in Southeast Asia. Its unique properties have garnered significant interest from researchers and customers, as it can give users both stimulating and discomfort-relieving effects, depending on the dosage.
In this simple guide, we will explore the facts of Mitragynine, taking you through where it comes from, the possible effects, and some ways you can take it. Our goal is to give you an in-depth understanding of this fascinating compound and help you make informed decisions when it comes to Kratom use. So, without further ado, let’s embark on this educational journey to uncover some of the secrets of Mitragynine.


Native regions: Southeast Asia

Kratom, scientifically known as Mitragyna speciosa, is a tropical evergreen tree native that grows abundantly in the lush rainforests of Southeast Asia. Kratom is popularly grown in countries like Thailand, Malaysia, and Indonesia.
We actually source all of GRH Kratom’s raw products from a single family-owned farm in Indonesia!
The tree thrives in this region’s warm and humid climate, and they can grow quite tall. It’s much easier to grow a kratom tree in tropical climates like these, and harder to grow them in many parts of the US.

Cultural significance and traditional uses

For centuries, Kratom has played a significant role in the traditional practices and cultural routines of local communities in Southeast Asia (where it was legal- kratom was banned in Thailand up until a few years ago). Laborers and farmers often chewed the fresh leaves to combat fatigue, increase productivity, and relieve aches and other discomfort from their long days and demanding work.

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The leaves: a source of alkaloids

Mitragynine and 7-hydroxymitragynine
The unique effects of Kratom can be attributed to the presence of various alkaloids found in its leaves. Among these alkaloids, Mitragynine and 7-hydroxymitragynine are the most prominent and well-studied compounds. Mitragynine typically constitutes the majority of the total alkaloid content, while 7-hydroxymitragynine is present in much smaller quantities. However, it’s important to note that 7-hydroxymitragynine is quite a bit more potent than Mitragynine.

Other alkaloids and their roles

In addition to Mitragynine and 7-hydroxymitragynine, Kratom leaves contain over 40 other alkaloids, each playing a part in the plant’s overall effects. Some of these alkaloids include paynantheine, speciogynine, and speciociliatine, among others. These compounds interact with various receptors in the human body, resulting in a complex and wide range of effects that can vary depending on the specific strain, region, and more.

Understanding Mitragynine

How it interacts with the human body

1. Affinity for opioid receptors

Mitragynine primarily interacts with the mu-opioid receptors (MOR) and kappa-opioid receptors (KOR) in the human body. Its ability to bind with these receptors is what makes it functionally similar (although much weaker) to some opioids. However, there are key differences in how Mitragynine interacts with these receptors compared to stronger options..

2. Partial agonist vs full agonist

While traditional opioids are full agonists of the MOR, meaning they are able to fully activate the receptor, Mitragynine acts as a partial agonist. This distinction is crucial, as it means that Mitragynine can produce some of the same effects as full agonists but with much less potency than they would have.

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Effects of Mitragynine

  • Relief from discomfort
    One of the most well-known and often-reported effects of Mitragynine is its ability to alleviate some discomfort. Its interaction with receptors can produce pleasant effects, which can be beneficial for individuals suffering from discomfort.
  • Stimulation at low doses
    Interestingly, Mitragynine may also produce stimulant effects at low doses. Users often report increased energy, enhanced focus, and a general sense of well-being when consuming small amounts of Kratom, making it a popular choice for those seeking a natural alternative to caffeine or other pick-me-up products out there.
  • Sedation at high doses
    On the flip side, at higher doses, Mitragynine can potentially bring on slightly sedative effects. This property has been useful to help promote relaxation and improve sleep quality.
  • Potential side effects
    Although Mitragynine offers various potential benefits, it is crucial to be aware of its possible side effects. Some users may experience nausea, dizziness, constipation, or dry mouth. Again, we aren’t medical professionals and this is not medical advice, just what our general understanding is.

How to Take Mitragynine

Traditional methods of Kratom consumption

  • Chewing fresh leaves
    In its native regions, the most traditional way of taking kratom is by chewing the fresh leaves, which releases the alkaloids, including Mitragynine, into the user’s system. This method is still a popular practice today in some areas of Southeast Asia, providing a quick and direct way to enjoy the effects of Kratom.
  • Brewing tea
    Another common traditional method of taking kratom is by brewing a tea from the dried or crushed leaves. The hot water extracts the alkaloids, producing a drink that works either hot or cold. This method allows for a more controlled dosage and a slower onset of the alkaloids in the system, which can be a nicer experience for some users.
  • Powdered form
    Dried Kratom leaves can also be ground into a fine powder, which can then be mixed with water or other liquid for consumption. The powdered form offers many options, as it can be easily added into various recipes or put into capsules for convenience.

Modern methods and innovations

  • Capsules and tablets
    For customers looking for a more convenient and discreet way to take kratom, capsules and tablets have become quite popular. These products contain a specific amount of Kratom powder, giving users with a consistent and easily controlled dose. Capsules and tablets also help cover up the bitter taste of Kratom, making them much easier to take for many users.
  • Tinctures and extracts
    Kratom tinctures and extracts are highly concentrated liquid forms of Mitragynine and other alkaloids. These products are made by dissolving Kratom powder and extracting the active compounds. The resulting liquid can then be consumed directly or mixed with other beverages. Tinctures and extracts offer a very strong and fast-acting way to get the effects of Kratom. But you should be cautious if using them, due to their high concentration.

Try our new kratom extract shots- King K. Premium kratom shots that you can trust. 

Importance of quality and purity

As with any consumable product, the quality and purity of Kratom are essential for ensuring safety and efficacy. At GRH Kratom, we prioritize the highest quality Kratom products, sourcing only from reputable and responsible suppliers. By adhering to strict quality control measures, we ensure that our customers receive products that are safe, pure, and free from contaminants. We also do third-party lab testing on our products, so you can see for yourself their safety and quality.

Final Thoughts on Mitragynine and Kratom

As we’ve seen, Mitragynine offers a range of potential benefits. The potential benefits include relief and stimulation at low doses to sedation at higher doses.
At GRH Kratom, we are committed to providing high-quality Kratom products and educating our customers about them. We encourage you to explore our product offerings, as well as our educational resources, to gain a deeper understanding of Kratom.
By staying informed and engaging in responsible consumption, you can contribute to the ongoing conversation surrounding Kratom and its alkaloids. This conversation will decide the future of this remarkable plant and its potential applications.



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